帕金森病直立性低血压与认知功能障碍的关系
| 作者: |
1殷康福,
1周传彬,
1徐忠
1 昆明医科大学第一附属医院老年神经内科，昆明 650032 |
| 通讯: |
徐忠
Email: xz0702@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2021.04.028 |
| 基金: | 国家自然科学基金地区基金(81960242)；昆明医科大学- 云南省科技厅联合专项[2019FE001(-048)]。 |
摘要
帕金森病(Parkinson’s disease，PD)是一种常见的中老年神经系统退行性疾病，临床上以运动和非运动症状(non-motor symptoms，NMS)为特征。自主神经系统功能障碍是PD最常见的NMS之一，可出现在PD早期或前驱阶段，有助于PD的早期诊断、评估疾病严重程度、预后和预测对治疗的反应。直立性低血压(orthostatic hypotension，OH)和认知障碍在PD非运动症状中最为常见，两者似乎是相互关联的，这种关系是因果关系还是共并关系，目前尚不清楚。目前PD-OH与认知功能障碍关系在国外已有较多的研究，而国内还未开展类似研究。
关键词：
帕金森病；直立性低血压；认知功能障碍；痴呆
Orthostatic hypotension and cognitive impairment in Parkinson’s disease
CorrespondingAuthor: XU Zhong Email: xz0702@126.com
DOI: 10.3978/j.issn.2095-6959.2021.04.028
Foundation: This work was supported by the Regional fund of National Natural Science Foundation of China (81960242) and Joint Project of Kunming Medical University and Yunnan Provincial Department of Science and Technology [2019FE001(-048)], China.
Abstract
Parkinson’s disease (PD) is a common nervous system degenerative disease occurring in the elderly, clinically characterized by motor and non-motor symptoms (NMS). Autonomic nervous system dysfunction is one of the most common NMS of PD. It can occur in the early or prodromal stage of PD, which is helpful for early diagnosis of PD, assessment of disease severity, prognosis and prediction of response to treatment. Orthostatic hypotension (OH) and cognitive impairment are the most common disorders of NMS in PD. It seems that they are related to each other. However, it is not clear whether the relationship is causal or coordinated. At present, there are many studies on the relationship between orthostatic hypotension and cognitive dysfunction in PD abroad, but there are no similar studies in China.
Keywords：
Parkinson’s disease; orthostatic hypotension; cognitive impairment; dementia