Objective: To study the effect of PDCA cycle on the safety management of stroke patients. Methods: Eighty-two stroke patients, who were treated in our hospital from January 1, 2017 to December 31, 2019, were randomly divided into the observation group and the control group. Each group had 41 patients, routine care was applied to the control group, PDCA cycle nursing was applied to the observation group, and the NIH Stroke Scale (NIHSS) score, Activity of Daily Living Scale (ADL) score, incidence of adverse events, and patient satisfaction with nursing work. Results: Before the care, there was no significant difference in the NIHSS score and ADL score (P>0.05). After different treatments, the NIHSS score and ADL score of the 2 groups were improved. Compared with the pre-care, the differences were significant (P<0.05), but the magnitude of improvement in the observation group was significantly greater than that in the control group. The NIHSS score and ADL score of the two groups were significantly different (P<0.05); the incidence of adverse events (4.88%) in the observation group was lower than that in the control group (21.95%). The difference was significant (P<0.05); the satisfaction of patients in the observation group (97.56%) was higher than that in the control group (75.61%), and the difference was significant (P<0.05). Conclusion: Applying PDCA cycle management to the nursing safety management of stroke patients can effectively improve the patient’s neurological function and improve the ability of daily living of patients. There are fewer adverse events. Patients have higher satisfaction with this kind of care, which has high promotion value.