Objective: To study the effect of hierarchical nursing intervention on ostomy tube care after stone removal in patients with kidney stones. Methods: From January 2018 to October 2019, 120 patients with nephrolithiasis who underwent lithotripsy were randomly divided into observation group and control group, with 60 cases in each group. The control group received routine nursing care of the ostomy tube after operation, and the observation group performed hierarchical nursing intervention on the ostomy tube after operation, and compared the nursing effects of the two groups. Results: In terms of surgery-related indicators, the urine clearing time, catheterization time, and hospital stay were (44.32±1.17) h, (4.08±0.95) d, and (9.42±1.76) d in the observation group; and (51.67±2.36) h, (6.24±1.41) d, (12.17±2.44) d in the observation group, respectively, the observation group was shorter than the control group, the difference was statistically significant (t=3.473, 5.692, 7.533, P<0.05); in the fistula In terms of the incidence of adverse events such as displacement, fistula blockage or obstruction, and unplanned extubation, the observation group was 5.00%, 1.67%, and 1.67%, which were all lower than the control group’s 18.33%, 13.33%, and 8.33%, with differences. Statistical significance (χ2=6.752, 6.128, 3.647, P<0.05). Conclusion: The use of hierarchical nursing interventions in postoperative ostomy tube care for patients undergoing kidney stone lithotripsy can strengthen the protection of the ostomy tube, reduce the occurrence of adverse events, and is conducive to the early recovery of patients after surgery. It is worth promoting and applying.