Objective: To analyze the CT imaging features of 2019 coronavirus disease, and provide some references for clinicians to diagnose novel coronavirus pneumonia. Methods: Twenty hospitalized patients, including 10 males and 10 females, aged 29–71 (46.8±11.7) years old, were selected from January 2019 to March 2019 during the outbreak of 2019 coronavirus disease in the First Affiliated Hospital of Anhui Medical University. The CT image characteristics and clinical data of different follow-up time were analyzed. Results: Eighteen cases were normal type, 2 heavy type. CT examination showed multiple lung lesions in 19 cases (95%), and single lung lesions in 1 case (5%). In 20 cases, 19 cases (95%) had patchy ground glass shadow, most of which were close to the subpleural area. Of 100 pulmonary lobes in 20 patients, 58 lobes (58%) had ground glass shadow lesions. Speckle consolidation was found in 29 leaves (29%). After hospitalization, chest CT was reexamined 5 days later, 8 patients were disease progression and 12 cases showed no significant changes. After 10 days, 4 cases progressed, 1 case showed no significant change, and 15 cases showed signs of absorption (75%). After 15 days, 15 patients were followed up, and all the patients showed signs of absorption (100%). Conclusion: The imaging features of 2019 coronavirus disease infection are mainly ground-glass opacity shadow. Multiple lesions are common in both lungs, mostly in the subpleural area. Pleural effusion or pericardial effusion are rare, and there are no enlarged mediastinal and hilar lymph nodes. Gradual absorption begins 10–15 days after treatment.