枸橼酸盐碱化尿液在高尿酸血症中的作用
| 作者: |
1岳丽丽,
1杜新
1 南京医科大学附属南京医院(南京市第一医院)肾内科，南京 210006 |
| 通讯: |
杜新
Email: duxin@njmu.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2020.07.032 |
| 基金: | 中华医学会临床医学科研专项基金(14050430580)；江苏省第15批六大高峰人才(WSN-113)。 |
摘要
随着社会经济的发展，人们生活水平的提高，我国高尿酸血症的患病率逐年增高，并呈年轻化趋势，已成为仅次于糖尿病的第二大代谢性疾病。枸橼酸盐应用于高尿酸血症不仅可防治尿酸结石，还可以降低血尿酸，改善肾功能，减少促进尿酸排泄药物的不良反应，在多个国内外指南和国内多个高尿酸血症专家共识推荐使用。
关键词：
高尿酸血症；碱化尿液；碳酸氢钠；枸橼酸盐
Role of citrate on urine alkalization in hyperuricemia
CorrespondingAuthor: DU Xin Email: duxin@njmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2020.07.032
Foundation: This work was supported by the Chinese Society of Nephrology (14050430580) and High-level Talents of the Fifteenth “Six Talents Peaks” in Jiangsu Province (WSN-113), China.
Abstract
With the development of economy and the improvement of living standard, the prevalence of hyperuricemia is on the increase in China. Hyperuricemia has become the second largest metabolic disease following diabetes mellitus. Citrate can not only prevent and treat uric acid calculi in hyperuricemia, but also reduce blood uric acid, improve renal function, and reduce adverse reactions of drugs which promote the excretion of uric acid. It has been recommended by numerous international guidelines and consensuses in hyperuricemia.
Keywords：
hyperuricemia; alkalized urine; sodium bicarbonate; citrate