Objective: To investigate the effect of reduced glutathione combined with naloxone on the time and quality of anesthesia recovery in patients with liver disease. Methods: Eighty-four patients with liver disease who underwent surgery in our hospital from September 2017 to December 2018 were randomly divided into three groups. Group A was treated with naloxone injection 0.01 mg/kg in the final intravenous bolus, Group B was given a reduced glutathione injection of 1.2 g based on group A, and was added to 10% glucose solution 100 mL intravenous drip was dripped within half an hour before the end of the operation. Group C did not give wake agent as a blank control group. The recovery time of spontaneous breathing, eye opening time, extubation time, extubation quality score, agitation score (RS score), sedation score (Ramsay score), operation time, anesthesia time, intraoperative fluid and urine volume were recorded. VRS pain scores were recorded after awakening and 30 min and 60 min after naloxone administration, as well as liver function (ALT and AST) before and 1 d after surgery. Results: Compared with group C, the extubation quality score and RS score of group A and group B decreased, and the Ramsay score increased (P<0.01). Compared with group A, group B had lower extubation quality score, RS score, and Ramsay score increased (P<0.05). Compared with group C, the respiratory recovery time, recovery time and extubation time of patients in group A and group B were shortened (P<0.01). Compared with group A, the respiratory recovery time, recovery time, and extubation time of group B patients were shortened (P<0.05). Conclusion: Reduced glutathione combined with naloxone can reduce the postoperative anesthesia recovery time of patients with liver disease and improve the quality of postoperative anesthesia recovery in patients with liver disease, and does not increase the postoperative pain score.