心肌肥厚与能量代谢最新研究进展
| 作者: |
1李博,
2李俊明
1 三峡大学医学院，湖北 宜昌 443000 2 三峡大学人民医院心内科，湖北 宜昌 443000 |
| 通讯: |
李俊明
Email: 1368545173@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.05.036 |
| 基金: | 国家自然科学基金(81873499)，宜昌市科技基金(A16-301-15)。 |
摘要
肥厚型心肌病是导致青少年心源性猝死的首要原因，其主要病理变化是发生了心肌肥厚，目前尚无有效的治疗手段。虽然心脏能够利用所有种类的底物，包括碳水化合物、脂类、氨基酸和酮体来提供能量，但它的底物选择在整个生命周期以及生理和病理状态下都会发生变化。代谢的灵活性使得心脏能够适应环境的变化，但在心肌肥厚的心脏中，底物选择的变化可能是有害也有可能是有益的。
关键词：
心肌肥厚；能量代谢：肥厚型心肌病
Recent advances in cardiac hypertrophy and energy metabolism
CorrespondingAuthor: LI Junming Email: 1368545173@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.05.036
Foundation: This work was supported by the National Natural Science Foundation (81873499) and Yichang Science and Technology Fund (A16-301-15), China.
Abstract
Hypertrophic cardiomyopathy is the leading cause of sudden cardiac death in adolescents. The main pathological change is cardiac hypertrophy. There is no effective treatment. Although the heart is able to provide energy using all kinds of substrates, including carbohydrates, lipids, amino acids, and ketone bodies, its substrate selection changes throughout the life cycle as well as under physiological and pathological conditions. Metabolic flexibility allows the heart to adapt to changes in the environment, but in cardiac hypertrophied hearts, changes in substrate selection may be harmful or potentially beneficial. This article will review the changes in myocardial cell energy metabolism during cardiac hypertrophy.
Keywords：
cardiac hypertrophy; energy metabolism; hypertrophic cardiomyopathy