妊娠期糖尿病与妊娠早期甲状腺功能状态的相关性
| 作者: |
1陈丽锦,
1王烨,
1李娟,
1陈甜花,
1甘月滨
1 厦门大学附属妇女儿童医院医学检验科，福建 厦门 361000 |
| 通讯: |
甘月滨
Email: 1269817906@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2020.05.016 |
摘要
目的：探究妊娠期妇女孕早期促甲状腺素(thyroid stimulating hormone，TSH)和抗甲状腺过氧化物酶抗体(thyroid peroxidase antibody，TPOAb)与妊娠期糖尿病(gestational diabetes mellitus，GDM)的相关性。方法：回顾性分析厦门市1 664名妊娠妇女孕早期TSH及TPOAb水平与孕中期糖耐量筛查试验结果的相关性，比较其发病率差异。结果：妊娠早期TSH和TPOAb与GDM的发病率差异无统计学意义(P=0.740，P=0.492)；GDM组TSH水平稍降低于非GDM组，但差异无统计学意义(P=0.175)；无论TPOAb阳性(OR=0.758，95%CI：0.470~1.235)或TSH水平升高(OR=0.903，95%CI：0.649~1.272)，或TPOAb阳性合并TSH水平升高(OR=1.038，95%CI：0.610~1.781)均未增加GDM的发生风险。结论：孕早期TSH和TPOAb水平异常不增加GDM的发病率，但妊娠期甲状腺功能状态与GDM相关性仍需进一步的研究。
关键词：
妊娠期糖尿病；促甲状腺激素；抗甲状腺过氧化物酶抗体；相关性
Correlation between gestational diabetes mellitus and thyroid function during early pregnancy
CorrespondingAuthor: GAN Yuebin Email: 1269817906@qq.com
DOI: 10.3978/j.issn.2095-6959.2020.05.016
Abstract
Objective: To explore whether there is a correlation between thyroid stimulating hormone (TSH) or thyroid peroxidase antibody (TPOAb) and gestational diabetes mellitus (GDM) in pregnant women during early pregnancy. Methods: The correlation between TSH and TPOAb levels in early pregnancy and the results of glucose tolerance screening test in second pregnancy in 1 664 pregnant women in Xiamen city was retrospectively analyzed, and the differences in incidence were compared. Results: There was no significant correlation between TSH or TPOAb in early pregnancy and the incidence of GDM (P=0.740, P=0.492); TSH levels in the GDM group were slightly lower than those in the non-GDM group, but there was no statistical difference (P=0.175). Either TPOAb-positive (OR=0.758, 95% CI: 0.470–1.235) or elevated TSH level (OR=0.903, 95% CI: 0.649–1.272), or TPOAb-positive combined with elevated TSH level (OR=1.038, 95% CI: 0.610–1.781) did not increase the risk of GDM. Conclusion: Abnormal TSH and TPOAb levels in early pregnancy did not increase the incidence of GDM, but the correlation between thyroid function and GDM in pregnancy still needs further study.
Keywords：
gestational diabetes; thyroid stimulating hormone; thyroid peroxidase antibody; correlation