Objective: To investigate the effect of enteral nutrition on serum inflammatory factors and cardiac function in elderly patients with heart failure. Methods: One hundred and five eligible elderly patients with heart failure were randomly divided into Group A, B and C, with 35 cases per group. Group A was treated with 500 mL/d enteral nutrition for 1 month. Group B was given the same treatment of Group A but for 3 months, and Group C was given daily diet. Nutritional status, changes in cardiac function and inflammatory factors were recorded before and after treatment, as well as major adverse cardiac events, including cardiogenic death, myocardial infarction, and stroke during treatment. Results: After the treatment, the nutritional status indicators, including body mass index, triceps skin fold thickness, upper arm muscle circumference, total protein, albumin, and hemoglobin, in Group A and Group B were higher than those before the treatment, and Group B showed more obvious improvement than Group A (P<0.05); there was no significant change in the nutritional status indicators before and after the treatment in group C (P<0.05); after the treatment, the cardiac function of Group A and Group B was better than that before the treatment (P<0.05). The expression of inflammatory factors, including tumor necrosis factor, interleukin 6, and C-reactive protein, decreased, and the improvement of cardiac function and expression of inflammatory factors in Group B was more obvious than that in Group A (P<0.05); there was no significant change in cardiac function and expression of inflammatory factors before and after treatment in Group C (P>0.05). There were no major adverse cardiac events in Group A and Group B during the treatment, and there was one case of myocardial infarction in Group C. Conclusion: Enteral nutrition can not only improve the nutritional status and cardiac function of elderly patients with heart failure, but also reduce the expression of inflammatory factors. And the longer the treatment time is, the more obvious the effect of improving cardiac function and reducing inflammatory factors is.