Objective: To observe and analyze the clinical application effect of case management model in patients with chronic heart failure. Methods: Altogether the inpatients with chronic heart failure who were treated in Department of Cardiology in Tenth Hospital Affiliated to Tongji University; 20 patients from July 2017 to October 2017 were selected as the control group and 20 patients from November 2017 to February 2018 were selected as the experimental group. The control group received the conventional management mode during the course of treatment; while the experimental group received the case management mode during the course of treatment. The difference between the management of patients with chronic heart failure of two groups were compared. Results: There was no significant difference in the scores of SAS and SDS between the two groups before intervention (P>0.05). After the intervention, the SAS and SDS scores of the two groups were decreased, and the difference was statistically significant (P<0.05) compared with the pre-intervention group. After the intervention, the SAS and SDS scores of the experimental group were lower than those of the control group, and the difference was statistically significant (P<0.05). The score of quality of life in the experimental group was higher than that in the control group (P<0.05). There was no significant difference in hospitalization time and hospitalization expenses (P>0.05). Conclusion: Case management model can effectively improve the quality of life of patients and psychological state of patients with heart failure, and it is recommended to be widely used in clinic.