Objective: To investigate the association between pathological TN staging and tumor deposits in colon cancer. Methods: Pathological data of 257 colon cancer cases from 2017 to 2018 was retrospectively analyzed. According to the 8th edition of the American Joint Committee on Cancer (AJCC) staging manual, all patients were devided into T2, T3 and T4 groups, N0, N+(N1+N2) groups, tumor deposits positive and negative group. R×C chi-suqare test was performed to analyze the correlations of T and N stage with tumor deposits. Using the chi-square decomposition to further pairwise comparison. Results: Of which, 2 cases (5.6%) with tumor deposits positive in T2 group, 30 cases (14.6%) in T3 group, 10 cases (66.7%) in T4 group. Chi-square test showed that tumor deposits during three groups were statistically different (χ2=31.327, P<0.05 respectively). Pairwise comparison showed that the incidence of tumor deposits in T2 and T3 groups was lower than those of the T4 group, the difference with statistical significance (χ2=21.976, 25.606, respectively and P<0.016, P<0.016 respectively). Nevertheless, there was no significant difference between T2 and T3 groups (P=0.141). In the N staging, 7 cases (4.2%) with tumor deposits in N0 group, 21 cases(22.8%) in N1 group, 14 cases (15.2%) in N2 group. Chi-square test showed significant different between N0 and N+ groups (χ2=49.360, P<0.001 respectively). Subgroup analysis was carried by N+ group, the difference between N1 and N2 groups was not statistically significant (χ2=3.091, P=0.079). Conclusion: T4 and N+ staging colon cancer patients have the higher risk of tumor deposits than other stages, tumor deposits is associated with elevating pathological T and N staging in colon cancer.