1 遵义医科大学附属医院病理科，贵州 遵义 563003
2 遵义医科大学附属医院影像科，贵州 遵义 563003
收集了遵义医科大学附属医院3例卵巢硬化性间质瘤(sclerosing stromal tumor of ovary，SST)的临床及影像学资料，采用光镜及免疫组织化学方法观察其病理特征并复习有关文献，探讨SST的临床病理学特点、诊断、鉴别诊断及预后。3例SST患者平均年龄48.7岁，主要临床表现为月经不调、绝经后阴道出血、盆腔包块等。肿瘤均为单侧发病，表面光滑，有完整包膜，切面实性或囊实性，灰黄灰白，质韧。低倍镜下可见具有特点的假小叶形成。免疫表型示：肿瘤细胞表达Vimentin，inhibin，TFE3及SMA。SST临床及影像学无明显特异性，诊断主要靠常规病理学，应注意与卵巢其他肿瘤鉴别。治疗推荐手术切除，一般预后较好。关键词： 硬化性间质瘤；卵巢；临床病理特征
Clinicopathologic analysis of 3 cases of sclerosing stromal tumor in the ovarian
CorrespondingAuthor: ZHENG Hong Email: email@example.com
Foundation: This work was supported by Zunyi Science and Technology Bureau Joint Foundation, China (2018070).
This paper collected the clinical and imaging data of 3 cases of sclerosing stromal tumor of ovary (SST) in our hospital, and observed the pathological features of the cases by means of microscopic and immunohistochemistry, with a review of literature. We investigated the clinicopathologic features, diagnosis, differential diagnosis and prognosis of SST. The average age of 3 patients was 48.7 years. The main clinical manifestations were irregular menstruation, postmenopausal vaginal bleeding, lower abdominal distention and pain. Tumors were unilateral, smooth surface, complete capsule, solid or cystic solid section, gray-yellow, gray-white, tough. At low magnification, characteristic pseudo lobules could be seen. Immunophenotype showed that tumor cells expressed Vimentin, inhibin, TFE3, and SMA. Ovarian sclerosing stromal tumors were rare and had no specific clinical and imaging features. The diagnosis mainly depends on routine pathology. We should pay attention to distinguishing them from other ovarian tumors. Surgical resection is recommended for treatment, and the prognosis is generally good.Keywords： sclerosing stromal tumors; ovarian; clinicopathological feature