Objective: To analyze the high-risk factors for eclampsia during repregnancy in patients with primary pregnancy-induced hypertension syndrome (PIH), in order to early recognize and intervent to high risk patients. Methods: A total of 124 repregnant patients diagnosed to primary PIH in our hospital from Oct. 2016 to Oct. 2018 were enrolled to respective research. All patients were divided into an observation group (n=37, the occurrence of eclampsia) and a control group (n=87, the non-occurrence of eclampsia) according to the occurrence of eclampsia during repregnancy. The primary pregnant age, gestational weeks, family history of PIH or eclampsia, hypertension recovering after primary pregnancy, pregnancies intervals, BMI of repregnancy, repregnancy weeks, serum vascular endothelial growth factor (VEGF) and placental growth factor (PLGF) levels of the 2 groups were recorded. The high-risk factors for eclampsia during repregnancy in patients with primary PIH were analyzed by univariate and multivariate logistic regression analysis. Results: Compared to the control group, the family history, hypertension without recovering, the serum levels of VEGF and PLGF at the primary pregnancy and repregnancy in the observation group were higher (P<0.05), but the intervals between pregnancies in the observation group were shorter (P<0.05). The family history, hypertension without recovering, intervals between pregnancies, serum levels of VEGF and PLGF were the independent high-risk factors for eclampsia during repregnancy by logistic regression analysis (P<0.05). Conclusion: The with family history, hypertension without recovering, intervals between pregnancies, high serum levels of VEGF and PLGF are high risks in patients with primary PIH, which should be given early intervention.