肺腺癌发生过程中相关蛋白质表达
| 作者: |
1侯丽娟,
2李丽,
2王琳,
2司彩风,
2张振华
1 山西医科大学研究生院，太原 030001 2 山西白求恩医院病理科，太原 030001 |
| 通讯: |
李丽
Email: Limuzi73@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.12.031 |
| 基金: | 山西省卫生健康委员会科研课题(2018012)。 |
摘要
肺癌发病率位于我国十大恶性肿瘤之首，腺癌是最常见的病理类型，其组织病理分型和分子生物标志物极具多样性，目前已成为研究的焦点。本文回顾了肺腺癌发生过程中相关基因在肿瘤实质细胞、间质细胞中的蛋白表达状况，为进一步探讨这些基因在肺腺癌发生发展过程中的作用提供理论依据，为肺癌的早期诊断提供思路。
关键词：
肺腺癌；低氧诱导因子；亲环蛋白A；二甲基精氨酸二甲基氨基水解酶2 ；转化生长因子β
Relevant protein expressions in the development of lung adenocarcinoma
CorrespondingAuthor: LI Li Email: Limuzi73@163.com
DOI: 10.3978/j.issn.2095-6959.2019.12.031
Foundation: This work was supported by Science Foundation of Health Commission of Shanxi Province, China (2018012).
Abstract
The incidence of lung cancer ranks first among the top ten malignant tumors in China. Adenocarcinoma is the most common pathological type. Its histopathologic classification and molecular biomarkers are very diverse, which has become the focus of research. This paper reviews the protein expression of related genes in tumor parenchymal cells and interstitial cells during the development of lung adenocarcinoma, providing theoretical basis for further exploring the role of these genes in the development of lung adenocarcinoma, and providing ideas for the early diagnosis of lung cancer.
Keywords：
lung adenocarcinoma; hypoxia-inducible factors; cyclophilin A; dimethylarginine dimethylaminohydrolase 2; transforming growth factor β