Objective: To investigate the relevant clinical factors affecting the postoperative efficacy of patients with anterior skull base meningioma. Methods: A retrospective analysis of clinical data of 61 patients with anterior skull base meningioma was conducted between January 2015 and January 2019 in the Affiliated Hospital of Xuzhou Medical University. The postoperative efficacy was comprehensively evaluated according to the preoperative and postoperative follow-up Karnofsky Performance Scale (KPS) of the patients. Statistical analysis of single factor and logistic regression model of multivariate factors were conducted to determine the relationship between each factor (gender, age, presence or absence of focal neurological dysfunction, pathologic grade, tumor size, tumor location, tumor texture, presence or absence of calcification or edema, extent of tumor resection, boundary of tumor and cerebral tissue, and inclusion of vascular nerves or not) and postoperative efficacy. Results: Single factor analysis results show the postoperative efficacy was significantly correlated with the presence or absence of focal neural dysfunction in patients, boundary between tumor and cerebral tissue as well as inclusion of vascular nerves or not (P<0.05), gender, age, pathologic grade, tumor texture, presence or absence of calcification or edema, tumor size, tumor location and extent of resection, however, were not correlated with the efficacy (P>0.05). Further dichotomy Logistic regression analysis demonstrated that presence or absence of focal neurological dysfunction and the inclusion of vascular nerves or not in the tumor were factors affecting the postoperative efficacy of the patients (P=0.004, P=0.023, respectively). Conclusion: The prognosis of patients with meningioma of the anterior cranial base without focal neurological dysfunction and tumor that does not surround vascular nerves is better.