Objective: To investigate treatment efficacy and safety of intrauterine balloon compression combined with uterine compression suture for patients with central and previa placenta with postpartum hemorrhage. Methods: Sixty patients with the central and previa placenta, who were treated at Qinhuangdao Maternal and Child Health Hospital from January 2015 to November 2018, were selected and their treatment data was retroactively analyzed. The duplex-methods group consisted of 29 patients treated by the uterine balloon compression combined with uterine compression suture. Thirty-one patients treated by the uterine compression suture was the suture group. The treatment efficacy, operative time, intraoperative and postoperative bleeding, postpartum complications, and length of stay (LOS) of the two groups were compared. Results: The hemostasis effect of the duplex-methods group was better than the suture group (P=0.039). The operation time, intraoperative and 24 h postoperative bleeding of the suture group was less than that of the duplex-methods group (both P<0.05). There were no significant differences for postpartum complications and LOS between these two groups (both P>0.05). Conclusion: The treatment efficacy for postpartum hemorrhage in patients with central and previa placenta treated by the intrauterine balloon compression combined with uterine compression suture was superior than the uterine compression suture used alone.