Objective: To investigate the effect of teriparatide on bone mineral density and its clinical efficacy in conservative treatment of senile intertrochanteric fractures. Methods: One hundred cases of senile femoral intertrochanteric fractures from March 2017 to March 1818 in Huidong People’s Hospital were retrospectively analyzed. The treatment was divided into observation group 55 cases and control group 45 cases. The two groups of patients were given basic conservative treatment. The observation group was treated with teriparatide on the basis of basic conservative treatment, and the control group was given subcutaneous injection of saline on the basis of basic conservative treatment. Comparing the time of getting out of bed, the time of fracture healing, the changes of bone markers, bone mineral density and the excellent rate of Harris score at different time points. Results: The time of getting out of bed and the time of fracture healing in the observation group were significantly shorter than those in the control group (P<0.05). At 1, 3, and 6 months after treatment, the N-terminal type I procollagen peptide (PINP), osteocalcin (OC) and bone-specific alkaline phosphatase (BSAP) were significantly increased compared with those before treatment, and C-terminal peptide type I collagen (CTX) was significantly decreased (P<0.05). Two groups of PINP, OC, BSAP There was a statistically significant difference in the interaction between CTX between groups, at different time points, between groups, and at different time points (P<0.05). At 1 month, 3 months, and 6 months after treatment, the two groups Bone mineral density was significantly increased compared with that before treatment (P<0.05). There was significant difference in the interaction between bone mineral density between groups, at different time points, between groups and at different time points (P<0.05). At the last 6 months, the excellent rate of Harries score in the observation group was significantly higher than that in the control group (P<0.05). Conclusion: Teriparatide is effective in the conservative treatment of senile intertrochanteric fractures, which can effectively improve the expression of serum bone markers and bone mineral density, promote joint function recovery, and has high clinical value.