AGGF1在乳腺癌中的表达与预后的关系
| 作者: |
1王波,
2董小林
1 湖北医药学院附属东风医院器官移植乳腺外科，湖北 十堰 442000 2 湖北医药学院附属人民医院健康管理中心，湖北 十堰 442000 |
| 通讯: |
董小林
Email: newestway@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.12.008 |
摘要
目的：探讨AGGF1(angiogenic factor with G and FHA domains 1)在乳腺癌中的表达及其与乳腺癌患者预后的意义。方法：利用免疫组织化学方法检测110例乳腺癌组织及配对癌旁正常组织AGGF1蛋白的表达，并分析其与临床病理指标的关系及对患者预后的影响。结果：在乳腺癌组织中，AGGF1蛋白阳性45例(41%)，AGGF1蛋白阴性65例(59%)；配对癌旁正常组织中，AGGF1蛋白阳性15例(13.6%)，AGGF1蛋白阴性95例(86.4%)；AGGF1在乳腺癌组织的表达明显高于配对癌旁正常组织，差异有统计学意义(P<0.05)。AGGF1蛋白表达与患者年龄、肿瘤大小、TNM分期、淋巴结转移等无相关性(P>0.05)；AGGF1蛋白表达与ER，PR，HER-2，增殖指数(Ki-67)等有相关性(P<0.05)。生存分析显示，AGGF1蛋白阳性表达患者的无病生存期(disease-free survival，DFS)与总生存期(overall-survival，OS)明显差于AGGF1蛋白阴性表达者，差异有统计学意义(P<0.05)。多因素COX比例风险回归模型分析发现：AGGF1蛋白阳性表达与乳腺癌患者的预后相关，为预后的独立预测因子。结论：在乳腺癌组织中，AGGF1蛋白阳性表达，与患者不良预后相关，可作为乳腺癌患者预后预测的指标，也有可能为潜在的治疗靶点。
关键词：
AGGF1；乳腺癌；免疫组织化学；预后
Expression of AGGF1 in breast cancer tissues and its prognosis
CorrespondingAuthor: DONG Xiaolin Email: newestway@163.com
DOI: 10.3978/j.issn.2095-6959.2019.12.008
Abstract
Objective: To investigate the expression and its significance of angiogenic factor with G and FHA Domains 1 (AGGF1) in breast cancer tissues. Methods: The levels of AGGF1 protein expression in 110 breast cancer and corresponding adjacent noncancerous tissues were assessed by immunohistochemistry. The potential associations of positive AGGF1 expression with clinicopathological variables and the prognosis of these patients were analyzed. Results: The positive and negative expression rate of AGGF1 expression in breast cancer and corresponding adjacent tissues were 41%, 59%, 13.6% and 86.4% respectively (P<0.05). The positive expression of AGGF1 in breast cancer tissues was positively associated with ER, PR, HER-2 and Ki-67 (P<0.05). There was no correlation between the age, tumor size, TNM stage and lymph node metastasis (P>0.05). Kaplan-Meier analyses revealed that the positive AGGF1 expression in breast cancer patients was significantly associate with a shorter disease-free survival and overall survival (P<0.05). Cox regression analyses indicated that the positive expression of AGGF1 was an independent prognosis factor for breast cancer patients. Conclusion: The positive AGGF1 expression may serve as a novel marker of poor prognosis and a potential therapeutic for breast cancer patients.
Keywords：
AGGF1; breast cancer; immunohistochemistry; prognosis