肠道菌群失调对结直肠癌发生、发展及诊疗影响的研究进展
| 作者: |
1周锋,
1王林,
1闫昌盛,
1刘冬晓,
1王拥卫,
1吴祥松
1 哈尔滨医科大学附属第一医院胰胆外科，哈尔滨 150001 |
| 通讯: |
吴祥松
Email: 13633621389@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.10.030 |
| 基金: | 国家自然科学基金 (81702384)；黑龙江省科技计划 (LCO8C25)；黑龙江省教育厅科学技术研究项目 (12541498)。 |
摘要
结直肠癌(colorectal cancer，CRC)是目前最常见的消化道恶性肿瘤之一，其发病率呈不断上升趋势。CRC是饮食、遗传、炎症等多因素共同作用的结果，其中肠道菌群失调在CRC的发生发展中起一定的作用。肠道菌群失调可通过破坏肠道黏膜屏障、诱导慢性炎症、产生毒性代谢产物等多种途径影响着CRC的发生发展。对肠道菌群失调与CRC发生发展的作用机制的研究将为CRC疾病的治疗提供新的靶点。
关键词：
结直肠癌；肠道菌群；代谢产物；失调；慢性炎症
Research progress of gut microbiota dysbiosis on the occurrence, development and diagnosis and treatment of colorectal cancer
CorrespondingAuthor: WU Xiangsong Email: 13633621389@163.com
DOI: 10.3978/j.issn.2095-6959.2019.10.030
Foundation: This work was supported by the National Natural Science Foundation (81702384), the Science and Technology Plan of Heilongjiang Province (LCO8C25)
Abstract
Colorectal cancer is one of the most common malignant tumors of digestive tract, and its incidence is on the rise. Colorectal cancer is the result of multiple factors such as diet, genetics and inflammation, among which gut microbiota dysbiosis plays a certain role in the occurrence and development of colorectal cancer. Gut microbiota dysbiosis can affect the occurrence and development of colorectal cancer through many ways, such as destroying intestinal mucosal barrier, induce chronic inflammation and producing toxic metabolites. Studys on the mechanism of intestinal flora imbalance and the occurrence and development of CRC will provide new targets for the treatment of CRC.
Keywords：
colorectal cancer; gut microbiota; product of metabolism; dysbiosis; chronic inflammation