Objective: To investigate the efficacy and safety of vacuum sealing drainage (VSD) in the treatment of soft tissue injury of bone trauma wounds. Methods: From May 2013 to December 2018, 74 patients with bone trauma wound soft tissue were randomly divided into an experimental group (VSD + conventional treatment, 37 cases) and a control group (conventional treatment, 37 cases). The clinical efficacy, treatment and complications were compared between the 2 groups. Results: The total effective rate of the experimental group was 91.9%, which was significantly higher than that of the control group (70.3%). The experimental group had a pain score of 2.2±0.9, antibacterial use time (3.4±1.2) days, dressing times (2.1±0.7) times, wound healing time (15.7±3.3) days, and total hospitalization time (17.9±2.9) days. The incidence of complications was 2.70%, and all indexes were superior to the control group (P<0.05). Conclusion: VSD is effective in treating soft tissue injury of bone wounds, which can effectively reduce complications and antibiotic use, significantly shorten treatment time, reduce patient suffering, accelerate tissue growth and wound healing, and is safe and effective, and worthy of clinical promotion.