Immunoelectron microscope technology is a method with combination of immunochemical technology and electron microscope, which can be used to observe and study the morphology and function of the cells and organs at the ultrastructural level by binding the labeled antibodies to specific antigens. It is divided into three types including immuno-iron protein technology, immuno-enzyme labeling technology and immune colloidal gold technique depending on different labeling methods. Among them, immune colloidal gold technique is more common to be used. At the electron microscope level, the gold particle has a high electron density and is clear distinguishable. Therefore, the secondary antibody combined with gold particles is used to react with the primary antibody to label the targeted antigen. In last decade, immune colloidal gold technique has made great progress for successfully applying to various aspects of cell biology, which provides much help for solving some medical problems under ultrastructural level.