ENO2在肾透明细胞癌中的表达及临床意义
| 作者: |
1方春天,
1席春生
1 中国人民解放军联勤保障部队第940医院肾内科，兰州 730050 |
| 通讯: |
席春生
Email: chunshxi@sina.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.09.009 |
| 基金: | 甘肃省自然科学基金(1606RJZA135)。 |
摘要
目的：分析ENO2基因在肾透明细胞癌及正常组织中的表达及其对预后的影响。方法：挖掘Oncomine及GEPIA数据库分析肾透明细胞癌及正常组织ENO2基因的相关数据，利用MethHc数据库分析ENO2基因在肾透明细胞癌及正常组织的甲基化水平，利用GEPIA数据库分析ENO2基因与肾透明细胞癌病理分期及生存期的相关性。结果：Oncomine及GEPIA数据库的数据显示与正常肾组织相比，ENO2在肾透明细胞癌中显著高表达；MethHc数据库的数据显示ENO2在肾透明细胞癌中的甲基化水平低于正常组织；ENO2基因的表达量与肾透明细胞癌预后存在负相关。结论：ENO2在肾透明细胞癌中高表达是影响预后的重要因素，ENO2可能是肾透明细胞癌潜在的预后生物学标志物。
关键词：
ENO2；肾透明细胞癌；数据库分析
Expression of ENO2 in clear cell renal cell carcinoma and its clinical influence
CorrespondingAuthor: XI Chunsheng Email: chunshxi@sina.com
DOI: 10.3978/j.issn.2095-6959.2019.09.009
Foundation: This work was supported by Gansu Natural Science Foundation, China (1606RJZA135).
Abstract
Objective: To analyze the expression changes of ENO2 in clear cell renal cell carcinoma and normal tissues and its effect on prognosis. Methods: The Oncomine and GEPIA databases were used to analyze the data of ENO2 gene in clear cell renal cell carcinoma and normal kidney tissues. The MethHc database was used to analyze the methylation level of ENO2 in clear cell renal cell carcinoma and normal kidney tissues. GEPIA database was used to analyze the correlation between ENO2 gene and pathological stage and survival time of patients with clear cell renal cell carcinoma. Results: The Oncomine and GEPIA databases showed that ENO2 was significantly higher in clear cell renal cell carcinoma than normal kidney tissue; the MethHc database showed that ENO2 was lower in methylation in clear cell renal cell carcinoma than in normal tissues; The expression of ENO2 gene is negatively correlated with the prognosis of clear cell renal cell carcinoma. Conclusion: High expression of ENO2 in clear cell renal cell carcinoma is an important factor affecting the prognosis. ENO2 may be a potential prognostic biomarker for clear cell renal cell carcinoma.
Keywords：
ENO2; renal clear cell carcinoma; database analysis