卵巢微囊性间质肿瘤1例
| 作者: |
1李佳美,
1陈敏,
1李奕锋,
1孙平丽
1 吉林大学第二医院病理科，长春 130022 |
| 通讯: |
孙平丽
Email: pinglisun@naver.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.08.038 |
| 基金: | 吉林省科技发展计划项目吉林省重点实验(20170622006JC)；吉林省财政厅项目(3D5177723429)。 |
摘要
对1例卵巢微囊性间质肿瘤(microcystic stromal tumor，MCST)患者进行临床、病理回顾性分析。患者，女，65岁，检查发现右侧卵巢肿物，肿物直径约12 cm，包膜光滑完整，切面呈囊实性。镜下肿瘤主要由微囊区、实性细胞丰富区及胶原纤维间质构成。免疫表型：β-catenin，Vimentin，WT1，CD10弥漫阳性，ER，PR，α-inhibin，calretinin，EMA均为阴性，Ki-67小于1%。
关键词：
卵巢微囊性间质肿瘤；β-连环蛋白；CTNNB1基因突变
Ovarian microcystic stromal tumor: A case report
CorrespondingAuthor: SUN Pingli Email: pinglisun@naver.com
DOI: 10.3978/j.issn.2095-6959.2019.08.038
Foundation: This work was supported by the Science and Technology Development Project of Jilin Province, Jilin Province Key Laboratory (20170622006JC) and Jilin Provincial Finance Department (3D5177723429)
Abstract
A clinical and pathological retrospective analysis was performed on a patient with microcystic stromal tumour (MCST), and the relevant literature was reviewed. A 65-year-old femal, who was found to have a right ovarian mass and the tumor was about 12 cm, with smooth envelope and solid-cystic cut surface. Microscopically, microcysts, solid area and hyaline degenerated fibrous stroma were variably mixed. Immunophenotype: tumor cells were diffusely and strongly positive for β-catenin, Vimentin, WT1, CD10, ER, PR, α-inhibin, calretinin, EMA were mostly negative, Ki67 labeling index was less than 1%. MCST is a relatively rare disease.
Keywords：
microcystic stromal tumor; β-catenin; CTNNB1 gene mutation