锌缺乏与糖尿病肾病的研究进展
| 作者: |
1赵世杰,
1王文荣,
1安惠霞
1 哈尔滨医科大学附属第二医院肾内科，哈尔滨 150000 |
| 通讯: |
安惠霞
Email: ahxsnk@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.08.035 |
摘要
锌是人体必需微量元素，在生物体中参与多种酶形成，可维持机体内环境稳态、加重氧化应激、促进间质纤维化、调控基因表达和介导细胞信号转导等。锌在体内缺乏可参与促进糖尿病肾病(diabetic nephropathy，DN)的发展，提示锌在DN发展中起重要作用。
关键词：
锌缺乏；慢性肾病；糖尿病肾病
Research progress in zinc deficiency and diabetic nephropathy
CorrespondingAuthor: AN Huixia Email: ahxsnk@163.com
DOI: 10.3978/j.issn.2095-6959.2019.08.035
Abstract
Zinc is an essential trace element and participates in numerous physiological processes. It can maintain the homeostasis of the body, aggravate oxidative stress, promote interstitial fibrosis, regulate gene expression, mediate cell signaling pathways and so on. The lack of zinc in the body can be involved in promoting the development of diabetic nephropathy, suggesting that zinc plays an important role in the development of diabetic nephropathy.
Keywords：
zinc deficiency; chronic kidney disease; diabetic nephropathy