Objective: To explore the effects of clustering nursing intervention on patients receiving long-range video electroencephalography (V-EEG) monitoring. Methods: From January 2017 to December 2018, a total of 240 patients undergoing long-range V-EEG monitoring in the Department of Neurology, the First Affiliated Hospital of Hainan Medical College were selected as the study subjects, and the patients were divided into an intervention group (n=120) and a control group (n=120) according to the random number table method. The control group was given routine nursing, and the intervention group was given cluster nursing program. The completion rate and success rate of long-range V-EEG monitoring and incidence rate of adverse events were compared between the two groups. Results: The completion and success rates of long-range V-EEG monitoring in the intervention group were both significantly higher than those in the control group (95.83% vs 88.33% and 97.39% vs 90.57%, respectively, P<0.05). Self-rating depression scale (SDS) and self-rating anxiety scale (SAS) in the intervention group were significantly lower than those in the control group (P<0.05). The compliance and satisfaction scores in the intervention group were significantly higher than those in the control group (P<0.05). The incidence rate of adverse reactions in the intervention group was significantly lower than that in the control group (2.50% vs 8.33%, P<0.05). Conclusion: Cluster nursing intervention for patients receiving long-range V-EEG monitoring can improve the completion and success rates of monitoring, and reduce the occurrence of adverse reactions, and it is conducive to the smooth implementation of diagnosis and treatment.