Objective: To evaluate the clinical efficacy of Xuanfei Pingchuan Recipe in treating children with asthma and its effect on exhaled nitric oxide (FeNO). Methods: Eighty children with bronchial asthma were divided into a control group and a study group according to the random number table method, 40 cases in each group. The control group was treated with Western medicine. The research group was treated with oral Xuanfei Pingchuan Recipe on the basis of Western medicine standard treatment. After 2 weeks of continuous treatment, the patients were compared in clinical efficacy, TCM symptom scores, inflammation index (WBC, hs-CRP, IL-6), lung function (FEV1, FEV1/FVC) and FeNO. Results: After the treatment, the total effective rate of the control group was 82.5%, and that of the study group was 92.5%. The clinical effect of the study group was better than that of the control group, and the difference was statistically significant (P<0.05). Before the treatment, the differences between the two groups in asthma, chest tightness, cough, cough and other symptoms were not statistically significant (P>0.05). After the treatment, the study group was better than the control group in terms of symptom improvement. The difference was statistically significant (P<0.05). After the treatment, the control groups were significantly improved except for the symptoms of chest tightness, and the difference was statistically significant (P<0.05). The study group showed significant improvement in each symptom, and the difference was statistically significant (P<0.05, P<0.01). Before the treatment, there were no significant differences in WBC, hs-CRP and IL-6 between the two groups (P>0.05). After the treatment, the inflammatory indexes of the study group were significantly lower than the control group, and the difference was statistically significant (P<0.05). After the treatment, the inflammatory indexes of the two groups were significantly decreased, and the difference was statistically significant (P<0.05, P<0.01). Before the treatment, there was no significant difference in the indexes of FEV1, FEV1/FVC and FeNO between the two groups (P>0.05). After the treatment, the indexes of the study group were significantly better than the control group, and the difference was statistically significant (P<0.01). After the treatment, the indexes of the two groups were significantly improved, and the difference was statistically significant (P<0.01). Conclusion: Xuanfei Pingchuan Recipe is effective in the treatment of children with asthma, can significantly improve the symptoms of children, reduce inflammation indicators, improve lung function, and have no obvious adverse reactions. The clinical efficacy is better when combined with western medicine treatment.