Objective: To observe the expressions of RECK, MMP-2 and C-FOS genes in laryngeal carcinoma tissues, adjacent normal tissues and normal mucosa tissues, and explore the correlation between them and clinicopathological features. Methods: A total of 45 cases of laryngeal carcinoma, 34 paraneoplastic tissues, and 10 normal mucosal tissues were collected in our hospital from January 2015 to July 2017. The expressions of RECK, MMP-2 and C-FOS mRNA and protein in each tissue were detected by PCR and Western blot, and their correlation with clinicopathological features was analyzed. Results: The expressions of RECK, MMP-2 and C-FOS mRNA and protein in laryngeal cancer group were 0.67±0.24, 3.05±0.14, 2.79±0.16, 4.15±2.33, 5.87±2.41, 3.25±2.63, respectively, compared with the normal group, the difference was statistically significant (all P<0.05). The expression of MMP-2 mRNA and protein in the laryngeal cancer group were 1.26±0.18, 3.57±1.74, compared with the paracancerous group, the difference was statistically significant (all P<0.05). The positive rates of RECK, MMP-2 and C-FOS in laryngeal cancer tissues with different pathological grades and clinical stages were statistically significant (all P<0.05). The positive rates of RECK and MMP-2 in laryngeal carcinoma with lymph node metastasis were statistically significant (all P<0.05). Conclusion: RECK, MMP-2 and C-FOS are expressed in different degrees in laryngeal carcinoma tissues, adjacent normal tissues and normal laryngeal mucosa tissues. RECK shows a low expression trend and high expression of MMP-2 and C-FOS in laryngeal carcinoma tissues.