Objective: To systematically evaluate the effectiveness of acupoint application of traditional Chinese medicine combined with point massage for adverse reaction after chemotherapy. Methods: Randomized controlled trials, which explored the effects of acupoint application of traditional Chinese medicine combined with point massage for adverse reaction after chemotherapy, were searched in the databases of Cochrane Library, PubMed, Web of Science, CNKI, VIP, Wanfang Data, CBM from inception to Nov. 2018, and a Meta-analysis was performed with RevMan5.3 software after screening the articles. Results: A total of 10 randomized controlled trials and 1 036 patients were enrolled, among which 518 cases were in an experimental and a control group respectively. According to the Meta-analysis: 1) the effectiveness of acupoint application of traditional Chinese medicine combined with point massage for nausea and vomiting after chemotherapy was significantly superior to the controlled treatment (OR=4.44, 95%CI 2.72–7.33, Z=5.98, P<0.00001); 2) the duration of vomiting was significantly decreased after comprehensive treatment (MD=−1.66, 95%CI −1.99 to −1.33, Z=9.82, P<0.00001); 3) the secondary outcome indicators in the experimental group indicated better efficiency when compared with those in the control group, such as hiccup symptom score, the efficacy of hiccup, constipation symptom score, defecation frequency, difficulty in defecating and first bowel movement, and there was significant difference (P<0.05). Conclusion: Acupoint application of Chinese traditional medicine combined with point massage is potentially effective to improve patient’s quality of life, and it is worth being popularized clinically. While the depth researches and high quality randomized controlled trials on the efficacy of acupoint application of Chinese traditional medicine combined with point massage for adverse reaction after chemotherapy will be needed to increase the strength of the argument in the future.