Objective: To explore the effects of whole-course nursing intervention based on health concept in the secondary prevention of ischemic stroke. Methods: A total of 116 patients with ischemic stroke from January 2017 to December 2018 in Wanbei Coal-Electricity Group General Hospital were selected and randomly divided into an observation group and a control group, with 58 cases in each group. The control group was given routine nursing measures, and the observation group was given whole-course nursing intervention based on health concept on the basis of control group. The self-management ability, psychological states and quality of life were compared between the two groups before and after nursing intervention. Results: The self-management score in the observation group after nursing intervention was higher than that in the control group (P<0.05). The scores of anxiety and depression after nursing intervention in the observation group were lower than those in the control group (P<0.05). The quality of life score in the observation group after nursing intervention was higher than that in the control group (P<0.05). Conclusion: Whole-course nursing intervention based on health concept is beneficial to the prevention of patients with ischemic stroke, and it can strengthen the self-management ability of patients, reduce anxiety and depression, and improve the quality of life.