血清上皮型脂肪酸结合蛋白与代谢综合征患儿心血管危险因素的相关性
| 作者: |
1王婧,
2秦钰,
3秦敬敏,
2韩艳珺,
4毕义猛,
5李雪琼,
1石振峰
1 邢台市人民医院内分泌科，河北 邢台 054000 2 邢台市人民医院儿科，河北 邢台 054000 3 邯郸市第二医院儿科，河北 邯郸 056000 4 唐山市丰南区妇幼保健院儿科，河北 唐山 063300 5 昆明医科大学第一附属医院内分泌科，昆明 650032 |
| 通讯: |
王婧
Email: wangjingwj2@126.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.08.009 |
| 基金: | 河北省邢台市科技局(2018ZC172)。 |
摘要
目的：探讨血清上皮型脂肪酸结合蛋白(epithelial fatty acid binding protein，E-FABP)与代谢综合征(metabolic syndrome，MS)患儿心血管危险因素的相关性。方法：选取2016年6月至2018年6月邢台市人民医院MS患儿、肥胖(非MS)儿童、正常儿童各50例，检测所有儿童的血清E-FABP、糖脂等生物化学指标，分析血清E-FABP与心血管危险因素的相关性。结果：MS患儿血清E-FABP明显高于肥胖儿童，肥胖儿童血清E-FABP明显高于正常儿童，差异有统计学意义(P<0.05)。Pearson相关性分析显示：E-FABP与BMI、胰岛素抵抗指数(insulin resistance index，HOMA-IR)、总胆固醇(total cholesterol，TC)、动脉粥样硬化指数(atherosclerosis index，AI)呈正相关(P<0.05)；多元逐步回归分析结果显示：E-FABP是AI的独立影响因素(P<0.05)。结论：E-FABP与MS发生及其心血管危险因素有关，可能可作为评估MS患儿心血管疾病发生的重要指标。
关键词：
上皮型脂肪酸结合蛋白；代谢综合征；儿童；心血管；危险因素；相关性
Association between serum epithelial fatty acid binding protein and cardiovascular risk factors in children with metabolic syndrome
CorrespondingAuthor: WANG Jing Email: wangjingwj2@126.com
DOI: 10.3978/j.issn.2095-6959.2019.08.009
Foundation: This work was supported by Hebei Xingtai Science and Technology Bureau, China (2018ZC172).
Abstract
Objective: To discuss the association between serum epithelial fatty acid binding protein (E-FABP) and cardiovascular risk factors in children with metabolic syndrome (MS). Methods: Fifty children with MS, 50 children with obesity (non-MS) and 50 normal children were selected from June 2016 to June 2018 in Xingtai People’s Hospital. All children were tested for serum E-FABP, glycolipid and other biochemical indicators, and the association between serum E-FABP and cardiovascular risk factors was analyzed. Results: The serum E-FABP of MS children were significantly higher than that of obese children, and the serum E-FABP of obese children was significantly higher than that of normal children, the difference was statistically significant (P<0.05). Pearson correlation analysis showed that the E-FABP were positively associated with BMI, insulin resistance index (HOMA-IR), total cholesterol (TC), atherosclerosis index (AI) (P<0.05). Multiple stepwise regression analysis showed that the E-FABP was the independent influencing factor of AI (P<0.05). Conclusion: E-FABP is associated with the occurrence of MS and its cardiovascular risk factors, which may be an important index for evaluating the occurrence of cardiovascular diseases in children with MS.
Keywords：
epithelial fatty acid binding protein; metabolic syndrome; children; cardiovascular; risk factor; association