31 例涎腺导管癌的临床病理分析
| 作者: |
1何时,
1何同梅,
1卢建平,
1许春伟,
1胡丹
1 福建医科大学附属福建省肿瘤医院病理科，福州 350014 |
| 通讯: |
胡丹
Email: 54511322@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.07.005 |
| 基金: | 福建省自然科学基金 (2016J01508，2018J01264)；福建省创新课题 (2017-CXB-2)；福建省卫生与计划生育委员会中青年骨干人才培养项目 (2016-ZQY-17)。 |
摘要
目的：探讨涎腺导管癌(salivar y duct carcinoma，SDC)的临床病理特征、诊断及鉴别诊断要点。方法：观察31例SDC的临床病理学特征，其中20例采用Ma xVi sion法行AR，HER-2，GATA3， Ki-67免疫组织化学染色，随访14~52个月，分析结果并复习相关文献。结果：SDC形态学上类似乳腺导管癌，肿瘤细胞通常为腺样、条索样、乳头样、实性，细胞异型性明显，通常可见导管原位癌成分。免疫组织化学分析20例SDC示：19例AR阳性，8例HER2阳性，19例GATA3阳性。结论：SDC是一种高度恶性的涎腺肿瘤，其预后较差，通常发生早期转移、局部复发。
关键词：
涎腺导管癌；病理特征；雄激素受体；人表皮生长因子受体；GATA结合蛋白3抗体
Clinicopathologic features of 31 cases of salivary duct carcinoma
CorrespondingAuthor: HU Dan Email: 54511322@qq.com
DOI: 10.3978/j.issn.2095-6959.2019.07.005
Foundation: This work was supported by the Fujian Provincial Natural Fund Project (2016J01508, 2018J01264); Fujian Province Innovation Project (2017-CXB-2); Young and Middle-aged Talents Training Project of Fujian Provincial Health Department (2016-ZQY-17)
Abstract
Objective: To investigate the clinicopathological features, the key points of the diagnosis and differential diagnosis of salivary duct carcinoma (SDC). Methods: The clinicopathological features of 31 patients with SDC were observed. Among them, 20 cases were subjected to immunohistochemical staining of androgen receptor (AR), HER-2, GATA3 and Ki-67 by MaxVision method. The follow-up period was 14–52 months. The results were analyzed and literature review was carried out. Results: The morphology of salivary ductal carcinoma is similar to that of breast ductal carcinoma. The tumor cells are usually adenoid, stripe like, papilloid and solid, with obvious heteromorphosis. Usually, ductal carcinoma in situ can be seen. Immunohistochemical analysis of 20 cases of parotid ductal carcinoma showed that 19 of them were AR positive, 8 were HER2 positive, and 19 were GATA3 positive. Conclusion: SDC is a highly malignant parotid tumor with a poor prognosis, usually with early metastasis and local recurrence.
Keywords：
salivary ductal carcinoma; pathological characteristics; androgen receptor; human epidermal growth factor receptor-2; GATA binding protein 3