文章摘要

肿瘤相关巨噬细胞作用和靶向治疗的研究进展

作者: 1王煦苏, 2徐娟, 2贾雪梅
1 南京医科大学妇产科学系，南京 211166
2 南京医科大学附属妇产医院(南京市妇幼保健院)妇产科，南京 210004
通讯: 贾雪梅 Email: xmjia@njmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2019.07.034
基金: 南京市医学科技发展重大项目 (ZDX16015)；江苏省研究生科研与实践创新计划项目 (SJCX18_0424)。

摘要

肿瘤微环境是一种复杂的细胞生态环境，其在向恶性肿瘤过渡期间与肿瘤细胞一起进化并提供支持。巨噬细胞特别富集并且存在于肿瘤进展的所有阶段，在原发性肿瘤中，肿瘤相关巨噬细胞(tumor associated macrophage，TAM)可以刺激血管生成并增强肿瘤细胞的侵袭，运动、内渗和耐药等能力，这些活动中的每一项都有不同的作用机制。
关键词： 肿瘤相关巨噬细胞；作用机制；靶向治疗

Research progress of tumor-associated macrophages in function and targeted therapy

Authors: 1WANG Xusu, 2XU Juan, 2JIA Xuemei
1 Department of Obstetrics and Gynecology, Nanjing Medical University, Nanjing 211166, China
2 Department of Gynecology, Women’s Hospital of Nanjing Medical University (Nanjing Maternity and Child Health Care Hospital), Nanjing 210004, China

CorrespondingAuthor: JIA Xuemei Email: xmjia@njmu.edu.cn

DOI: 10.3978/j.issn.2095-6959.2019.07.034

Foundation: This work was supported by the Medical Science and Technology Development Major Project of Nanjing (ZDX16015) and Jiangsu Provincial Graduate Research and Practice Innovation Program (SJCX18_0424), China.

Abstract

The tumor microenvironment is a complex ecology that evolves with and provides support to tumor cells during the transition to malignancy. Macrophages are particularly abundant and are present at all stages of tumor. In the primary tumor, macrophages can stimulate angiogenesis and enhance tumor cell invasion, motility, intravasation and drug resistance. Each of these activities has a different mechanism.
Keywords： tumor-associated macrophages; mechanism; targeted therapy

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