Notch3 在非肿瘤性肾病中作用机制的研究进展
| 作者: |
1常凯利,
1刘学光
1 复旦大学基础医学院病理学系，上海 200032 |
| 通讯: |
刘学光
Email: glxg69@shmu.edu.cn |
| DOI: | 10.3978/j.issn.2095-6959.2019.07.031 |
| 基金: | 国家自然科学基金 (81100505)。 |
摘要
Notch受体属于表皮细胞生长因子样家族的跨膜蛋白，广泛表达于细胞表面且呈高度保守，其与相邻细胞的配体相结合后参与多种细胞生命活动及器官发育。其中，Notch3受体在多种肾小球疾病、肾小管-间质疾病以及肾小球硬化或肾纤维化过程中呈显著活化，通过经典或非经典信号通路参与疾病的发生与发展。
关键词：
Notch3；肾小球疾病；肾小管间质损伤；纤维化
Advances in the mechanisms of Notch3 in non-neoplastic kidney diseases
CorrespondingAuthor: LIU Xueguang Email: glxg69@shmu.edu.cn
DOI: 10.3978/j.issn.2095-6959.2019.07.031
Foundation: This work was supported by the National Natural Science Foundation of China (81100505).
Abstract
Notch receptors are transmembrane proteins of the epidermal growth factor (EGF)-like families. They are widely expressed on the cell surface and highly conserved. Notch receptors modulate various cell life activities and organ development after binding to ligands of adjacent cells. Among them, Notch3 is significantly activated in various glomerular diseases, renal tubulointerstitial diseases, glomerulosclerosis or renal fibrosis, and participates in the development of kidney diseases through its canonical or non-canonical signaling pathways.
Keywords：
Notch3; glomerular diseases; tubulointerstitial injury; fibrosis