Objective: To study the effects of aerobic exercise combined with resistance training and diet adjustment on complications and quality of life in patients with type 2 diabetes mellitus (T2DM). Methods: Ninety-two patients firstly diagnosed as T2DM in our hospital from January 2018 to August 2018 were selected and divided into two groups according to the random number table method, with 46 cases in each group. Control group was given diet adjustment and aerobic exercise for intervention, and observation group was added with resistance training on this basis, and the two groups were intervened for 3 months. The changes of blood glucose, blood lipids and quality of life and the occurrence of T2DM complications were compared between the two groups after intervention. Results: After intervention, the levels of FBG, 2 h PG and HbA1c were significantly decreased in the two groups (P<0.05), and the levels of FBG, 2 h PG and HbA1c in the observation group were lower than those in the control group, and the levels of serum TG, TC and LDL-C were significantly decreased in the two groups (P<0.05), and the levels of serum TG, TC and LDL-C in the observation group were lower than those in the control group, and the scores of physiological function, mental spirit, social relationship and treatment of DSQL in the two groups were significantly increased (P<0.05), and the dimensions scores in observation group were higher than those in control group (P<0.05). The incidence rates of T2DM complications in observation group and control group were 6.52% and 13.04% respectively (P>0.05). Conclusion: Aerobic exercise combined with resistance training and diet adjustment intervention can significantly improve the blood glucose and blood lipids control levels and promote the quality of life of T2DM patients.