Objective: To compare and analyze the value of inhalation therapy of tiotropium bromide combined with salmeterol and fluticasone in patients with chronic asthmatic bronchitis. Methods: A total of 139 patients with chronic asthmatic bronchitis admitted to Nanchong Psychosomatic Hospital from March 2016 to September 2018 were selected. According to the odd even method, the patients were divided into an observation group and a control group. The control group was treated by thiamethoxam bromide inhalation only, and the observation group was treated with thiamethoxam bromide, salmeterol assigned to inhale treatment. Clinical efficacy and lung function improvement before and after the treatment were analyzed, and clinical symptom improvement time difference was recorded and compared. Results: The total clinical efficacy of the observation group was significantly better than that of the control group, and the indexes of pulmonary function after treatment were better than those of the control group (P<0.05). The improvement time of clinical symptoms in the observation group was shorter than that in the control group. Conclusion: The inhalation therapy of tiotropium bromide combined with salmeterol and fluticasone in patients with chronic asthmatic bronchitis is effective and worthy of promotion.