心肌肌球蛋白结合蛋白C在急性心肌梗死诊断中的研究进展
| 作者: |
1朱晓栋,
1戴海龙,
1尹小龙
1 云南省心血管疾病重点实验室，昆明医科大学附属延安医院心血管内科，昆明 650051 |
| 通讯: |
戴海龙
Email: 46944404@qq.com 尹小龙 Email: 269534795@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.05.031 |
| 基金: | 云南省自然科学基金 [2017FE467(-199)]；云南省卫生科研项目 (2014NS215)。 |
摘要
急性心肌梗死(acute myocardial infarction，AMI)起病急、致死率高，肌钙蛋白(cardiac troponin， cTn)因其灵敏度高、特异性强、AMI发病后在血液中出现时间较早，成为诊断AMI生物标志物的 “金标准”。心肌肌球蛋白结合蛋白C(cardiac myosin binding protein-C，cMyBP-C)是一种特殊的心肌肌小节蛋白，近年来已成为心血管疾病的研究热点之一。国内外多项研究发现：cMyBP-C水平在AMI的早期即可升高，具有作为一种新型心肌梗死生物标志物的潜能。
关键词：
心肌肌球蛋白结合蛋白C；肌钙蛋白；急性心肌梗死；生物标志物
Research progress of cardiac myosin binding protein C in the diagnosis of acute myocardial infarction
CorrespondingAuthor: DAI Hailong Email: 46944404@qq.com
DOI: 10.3978/j.issn.2095-6959.2019.05.031
Foundation: This work was supported by the Natural Science Foundation of Yunnan Province [2017FE467(-199)] and Yunnan Provincial Health Scientific Research Project (2014 NS215), China.
Abstract
Acute myocardial infarction (AMI) is characterized by acute onset and high mortality. Cardiac troponin (cTn) is characterized by its high sensitivity and specificity, and it appears in the blood earlier after the onset of AMI, so it has become the “gold standard” for the diagnosis of AMI biomarkers. Cardiac myosin binding protein C (cMyBP-C) is a kind of special myocardial sarcomere protein. In recent years, it has become one of the research hotspots in cardiovascular disease. Many studies at home and abroad have found that the level of cMyBP-C can be increased at the early stage of AMI, and has the potential as a new biomarker of AMI.
Keywords：
cardiac myosin binding protein C; cardiac troponin; acute myocardial infarction; biomarker