孢子丝菌病原学的研究进展
| 作者: |
1郭亚南,
1侴梦微,
1刘慧瑜
1 哈尔滨医科大学附属第一医院皮肤性病科，哈尔滨 150000 |
| 通讯: |
刘慧瑜
Email: 834806009@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.05.026 |
| 基金: | 黑龙江省青年科学基金 (QC2012C028)。 |
摘要
孢子丝菌病是一种世界性的慢性肉芽肿性真菌病，为人兽共患病，主要由孢子丝菌复合体感染而致病，可引起皮肤、黏膜及淋巴管的炎症。其传染源、传播方式和分布模式因致病菌种的不同而不同。其中，球形孢子丝菌主要引起固定型皮肤病变；巴西孢子丝菌毒性强，是与猫传播的孢子丝菌病最相关的物种。近年来动物感染的病例报道日渐增多，巴西地区也因出现暴发事件而备受国际关注。因此了解病原体的生物学特征以及致病菌种的流行病学特点对于疾病的诊治及预后至关重要。
关键词：
孢子丝菌病；病原学；致病菌种的流行病学；免疫应答
Advances in research on pathogenicity of sporotrichosis
CorrespondingAuthor: LIU Huiyu Email: 834806009@qq.com
DOI: 10.3978/j.issn.2095-6959.2019.05.026
Foundation: This work was supported by the Heilongjiang Youth Science Fund Project, China (QC2012C028).
Abstract
Sporotrichosis is a worldwide chronic granulomatous fungal disease that is zoonotic. It is mainly caused by infection by the sporozoite complex, which can cause chronic infectious inflammation of the skin, mucous membranes and lymphatic vessels. The source of infection, mode of transmission and distribution pattern vary depending on the pathogen. Among them, Sporothrix globosa mainly causes fixed cutaneous lesions. S. brasiliensis has highly toxic and is the most prevalent species related to cat transmitted sporotrichosis. In recent years, case reports of animal infections are increasing, and outbreaks in Brazil have also received international attention. Therefore, understanding the biological characteristics of pathogens and the epidemiological characteristics of pathogenic bacteria are crucial for the diagnosis and treatment of the disease.
Keywords：
sporotrichosis; etiology; epidemiology of pathogenic bacteria; immune response