缺血性脑卒中患者体内S100β，NPY，NSE水平及其临床意义
| 作者: |
1冯丽君,
1王昆
1 郑州市第一人民医院神经内科，郑州 450000 |
| 通讯: |
冯丽君
Email: zhengzhouyifenyuan@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.05.016 |
摘要
目的：观察缺血性脑卒中患者的中枢神经特异性蛋白(S100β)、神经肽Y(NPY)、神经元特异性烯醇化酶(NSE)水平，并分析其临床意义。方法：选取2017年2月至2018年2月在郑州市第一人民医院接受治疗的缺血性脑卒中患者为观察对象。根据其预后分为合并偏瘫组与未合并偏瘫组。选取同期在郑州市第一人民医院接受体检的健康成年人作为对照。观察不同组别S100β，NPY，NSE水平，NIHSS评分和认知功能的差异。采用相关分析法分析缺血性脑卒中患者S100β，NPY，NSE水平与认知功能和NIHSS评分的相关性。结果：缺血性脑卒中患者的S100β，NPY，NSE水平、 NIHSS评分均高于对照组(分别t=−52.865，−28.738，−32.462，−43.546，P<0.001)，认知功能低于对照组；偏瘫组患者的S100β，NPY，NSE水平，NIHSS评分均高于未合并偏瘫组(分别t=−6.155，−10.741，−8.899，−9.629，P<0.001)，认知功能低于未合并偏瘫组。相关分析结果显示：缺血性脑卒中患者的S100β，NPY，NSE水平与NIHSS评分呈正相关，与认知功能总分呈负相关。结论：S100β，NPY，NSE与缺血性卒中神经功能损害和认知障碍密切相关。
关键词：
脑卒中；神经肽；神经元特异性烯醇化酶；认知功能
Levels of S100β, NPY, NSE and their clinical significance in patients with ischemic stroke
CorrespondingAuthor: FENG Lijun Email: zhengzhouyifenyuan@163.com
DOI: 10.3978/j.issn.2095-6959.2019.05.016
Abstract
Objective: To analyze the levels of central nervous S100β, NPY and NSE in patients with ischemic stroke and their clinical significance. Methods: The patients with ischemic stroke treated in the First people Hospital of Zhengzhou from February 2017 to February 2018 were selected as the observation objects. According to the prognosis of the patients, they were divided into two groups: a hemiplegic group and a non-hemiplegic group. The healthy adults who received physical examination in our hospital during the same period were selected as the control group. We observed differences in S100β, NPY, NSE levels, NIHSS scores, and cognitive function in each group. Correlation analysis was used to analyze the correlation between S100β, NPY, NSE levels and cognitive function and NIHSS score in patients with ischemic stroke. Results: The levels of S100β, NPY, NSE and NIHSS in patients with ischemic stroke were higher than those in the control group (t=−52.865, −28.738, −32.462, −43.546, respectively; P<0.001), and cognitive function was lower than that of the control group. The S100β, NPY, NSE levels and NIHSS scores of the patients in the hemiplegia group were higher than those in the non-hemiplegia group (t=−6.155, −10.741, −8.899, −9.629, respectively; P<0.001), and the cognitive function was lower than that of the non-hemiplegia group. Correlation analysis showed that the levels of S100β, NPY, and NSE in patients with ischemic stroke were positively correlated with NIHSS scores and negatively correlated with total cognitive function. Conclusion: S100β, NPY, and NSE are closely associated with neurological impairment and cognitive impairment in ischemic stroke.
Keywords：
stroke; neuropeptide; neuron-specific enolase; cognitive function