Objective: To investigate the effect of magnetic bead auricular point pressing combined with Moxibustion on improving fatigue syndrome after gynecological laparoscopic surgery. Methods: From July 2017 to July 2018, 154 patients with gynecological laparoscopic surgery in our hospital were randomly divided into three groups: a routine group (n=50), an ear acupoint group (n=52) and a combined group (n=52). The routine group adopted routine nursing intervention scheme, the ear acupoint group used magnetic bead ear acupoint pressing dryer on the basis of the control group, and the combined group was treated with magnetic beads and auricular point pressing combined with moxibustion. The Visual Analogue Scale (VAS), Pittsburgh sleep quality index (PSQI), the first time of ambulation, time of anal exhaust and days of hospitalization were compared among the three groups. Results: After the intervention, there were significantly different among the VAS scores of the three groups (P<0.05), and the combined group < the ear acupoint group < the routine group, the difference between the two groups was statistically significant (P<0.05). There were significantly differences among each dimension and total scores of the PSQI in the three groups (P<0.05), and the combined group < the ear acupoint group < the routine group. The difference between any two groups was statistically significant. There were significant differences in the first time of ambulation, the time of anal exhaust, and the days of hospitalization among the three groups (P<0.05), and the combined group < the ear acupoint group < the routine group. Conclusion: Single use of magnetic bead auricular point pressing or combined moxibustion can reduce the symptoms of postoperative fatigue syndrome in patients after gynecological laparoscopic surgery, and the combined effect is better than single use of magnetic bead auricular point pressing, which is worthy of further promotion in clinical practice.