病毒性心肌炎与NETs的相关性
| 作者: |
1王丹,
1梁雨亭,
1塔娜,
1赵德超
1 哈尔滨医科大学附属第一医院心血管内科，哈尔滨 150001 |
| 通讯: |
赵德超
Email: drzhaodechao@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.04.032 |
摘要
病毒性心肌炎(viral myocarditis，VMC)威胁着人类健康，其慢性过程可发展为扩张型心肌病，影响患者生存及预后。先天免疫答应在VMC侵入阶段发挥重要作用，病毒诱导的中性粒细胞胞外诱捕网(neutrophil extracellular traps，NETs)既可以调控病毒，又可以破坏宿主，造成病理损伤，影响VMC的预后。本文全面概述了目前研究热点，即NETs是否与心肌炎存在潜在联系，旨在提供可能有助于改善VMC治疗的新手段。
关键词：
中性粒细胞胞外诱捕网；活性氧；NADPH氧化酶
Correlation between viral myocarditis and neutrophil extracellular traps
CorrespondingAuthor: ZHAO Dechao Email: drzhaodechao@163.com
DOI: 10.3978/j.issn.2095-6959.2019.04.032
Abstract
Viral myocarditis threatens human health, and its chronic process can develop into dilated cardiomyopathy, affecting the survival and prognosis of patients. Congenital immunity promises to play an important role in the invasion stage. Virus-induced extracellular neutrophil extracellular traps (NETs) can regulate the virus and destroy the host, cause pathological damage and affect the prognosis of viral myocarditis. In this review, we provided a comprehensive overview of the current research hotspot, that was, whether there was a potential association between NETs and myocarditis, in order to provide new discoveries that may help improve treatment for viral myocarditis.
Keywords：
neutrophil extracellular traps; reactive oxygen species; NADPH oxidase