血小板/淋巴细胞比率与多肌炎的相关性
| 作者: |
1莫家鹏,
1覃伟
1 恩施土家族苗族自治州中心医院神经内科，湖北 恩施 445000 |
| 通讯: |
覃伟
Email: qinweishenjing@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.04.018 |
摘要
目的：探究血小板/淋巴细胞比率(platelet to lymphocyte ratio，PLR)与多肌炎(polymyositis，PM)的相关性。方法：共纳入56例新诊断为PM的患者作为PM组，健康体检人群138例作为对照组。结果：PM组患者PLR水平显著高于对照组(156.3±87.8 vs 104.3±30.4，P<0.001)。Pearson相关性分析发现：PLR与中性粒细胞/血小板比率，红细胞沉降率(er y throcy te sedimentation rate，ESR)，血小板计数呈正相关(r=0.378，P=0.005；r=0.421，P=0.030；r=0.321，P<0.001)；PLR与淋巴细胞计数呈负相关(r=−0.832，P<0.001)。Logistic回归分析发现：PLR与PM具有独立相关性，其OR值为1.017 (95%CI 1.003~1.031；P=0.015)。PLR的ROC曲线下面积(area under the cur ve，AUC)为0.856(95%CI 0.637~0.824，P<0.001)。结论：PLR与PM具有一定相关性，PLR可作为诊断PM的临床生物标志物。
关键词：
血小板/淋巴细胞比率；多肌炎；相关性
Relationship between platelet to lymphocyte ratio and polymyositis
CorrespondingAuthor: QIN Wei Email: qinweishenjing@163.com
DOI: 10.3978/j.issn.2095-6959.2019.04.018
Abstract
Objective: To investigate the relationship between platelet to lymphocyte ratio (PLR) and polymyositis (PM). Methods: The present study included 56 newly diagnosed PM patients as PM group and 138 healthy subjects as control group. Results: PLR were higher in patients with PM compared with the healthy controls (156.3±87.8 vs 104.3±30.4, P<0.001). PLR was positively correlated with neutrophil to lymphocyte ratio, erythrocyte sedimentation rate (ESR), and platelet counts (r=0.378, P=0.005; r=0.421, P=0.030; r=0.321, P<0.001), and negatively with lymphocyte counts (r=−0.832, P<0.001) in patients with PM. In logistic regression analysis, PLR was independently associated with PM. The resulting odds ratio (OR) was 1.017 (95% CI 1.003–1.031, P=0.015) for PLR. The ROC curve showed that the diagnostic efficacy of PLR was 0.856 (95% CI 0.637–0.824, P<0.001). Conclusion: Our research suggests that PLR is associated with PM, and PLR may be used as a clinical risk factor to predict the occurrence of PM.
Keywords：
platelet to lymphocyte ratio; polymyositis; relationship