Objective: To investigate the effect of Sjogren’s syndrome on fetal and pregnancy outcomes in pregnant women. Methods: Forty-eight pregnant women with Sjogren’s syndrome were selected as study subjects, and 96 normal subjects matched with age and body mass index were selected as control group. According to whether the patients had regular treatment before pregnancy, they were divided into regular treatment group and irregular treatment group. The relationship between Sjogren’s syndrome and abnormal pregnancy was analyzed. Results: The rate of spontaneous abortion in Sjogren’s syndrome group was significantly earlier than that in the control group (38 weeks+3 days vs 39 weeks+2 days). The incidence of spontaneous abortion was much higher that of the Sjogren’s syndrome group (15% vs. 9%, P=0.04). The activity of Sjogren’s syndrome had a significant effect on the percentage of birth weight. One case of congenital heart block fetus happened. Conclusion: The incidence of premature delivery and the proportion of low-specific foetus in Sjogren’s syndrome pregnancy are significantly higher than those in the healthy control group. Anti-Sjogren’s antibody is related to spontaneous abortion.