肌萎缩侧索硬化血清白蛋白与疾病严重程度的相关性
| 作者: |
1朱江,
1赵斌,
1黄永锋,
1王迎,
2闫炳苍,
1张宏,
1封婷
1 榆林市第一医院神经内科，陕西 榆林 719000 2 西安中医脑病医院神经内科，西安 710032 |
| 通讯: |
赵斌
Email: zhenbeitai@163.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.03.014 |
| 基金: | 陕西省中医药管理局基金资助项目 (LCMS022)。 |
摘要
目的：探讨肌萎缩侧索硬化(amyotrophic lateral sclerosis，ALS)患者血清白蛋白与疾病严重程度的关系。方法：收集经临床确诊的60例ALS患者进行了随访和评估，另选60例周围神经病作为对照组，对两组年龄、性别、胆固醇、三酰甘油、低密度脂蛋白、血清白蛋白、尿素、尿酸方面进行对比分析，肌萎缩侧束硬化的严重程度由专门神经内科医师行ALS功能量表修订版(ALS Function Scale，ALSFRS-R)评估，并进行ALSFRS-R评分与血清白蛋白相关性分析。结果：ALS组血清白蛋白为(42.51±4.89) mmol/L，周围神经病组血清白蛋白为(44.61±5.44) mmol/L，两组比较差异有统计学意义(P<0.05)。两组在胆固醇、三酰甘油、低密度脂蛋白、尿素、尿酸比较差异无统计学意义(P>0.05)。ALS患者血清白蛋白与患者ALSFRS-R评分做相关性分析显示呈正相关(r=0.306， P<0.05)。结论：血清白蛋白计算简便，是一个有效快捷的评估ALS疾病严重程度的指标，具有一定的临床应用价值。
关键词：
肌萎缩侧索硬化；血清白蛋白；ALS功能量表修订版评分；疾病严重程度
Correlation of serum albumin and severity of amyotrophic lateral sclerosis
CorrespondingAuthor: ZHAO Bin Email: zhenbeitai@163.com
DOI: 10.3978/j.issn.2095-6959.2019.03.014
Foundation: This work was supported by the Project Foundation from Shaanxi Provincial Administration of Traditional Chinese Medicine, China (LCMS022).
Abstract
Objective: To investigate the relationship between serum albumin and the severity of amyotrophic lateral sclerosis (ALS). Methods: Sixty patients with amyotrophic lateral sclerosis were followed up and evaluated. Sixty patients with peripheral neuropathy were selected as control group. Age, sex, cholesterol, triglyceride, low-density lipoprotein, urea and uric acid were compared between the two groups. The severity of amyotrophic lateral tract sclerosis was assessed by specialist neurologists with the revised ALS Function Scale (ALSFRS-R), and the correlation between ALSFRS-R score and serum albumin was analyzed. Results: The serum albumin level in ALS group was (42.51±4.89) mmol/L, and that in peripheral neuropathy group was (44.61±5.44) mmol/L, and there was a significant difference between two groups (P<0.05). There was no significant difference in cholesterol, triglyceride, low density lipoprotein, urea and uric acid between the two groups (P>0.05). There was a positive correlation between serum albumin and ALSFRS-R score (r=0.306, P<0.05). Conclusion: Serum albumin is an effective and rapid index for evaluating the severity of amyotrophic lateral sclerosis, and has a certain clinical value.
Keywords：
amyotrophic lateral sclerosis; serum albumin; ALS Function Scale score; severity of disease