KISS1 与KAI1 在结肠癌中的表达及临床意义
| 作者: |
1王哲彦,
2孟玉秋,
1刘春玲,
1孟令超,
1马小兵,
3王志鹏
1 唐山市人民医院病理科，河北 唐山 063000 2 唐山市丰南区中医院病理科，河北 唐山 063300 3 唐山市人民医院普外科，河北 唐山 063000 |
| 通讯: |
王哲彦
Email: 153874817@qq.com |
| DOI: | 10.3978/j.issn.2095-6959.2019.03.008 |
| 基金: | 河北省医学科学研究重点课题 (20181235)。 |
摘要
目的：探讨KISS1与KAI1在结肠癌组织中的表达及临床意义。方法：收集80例行结肠癌根治术患者的术后病理标本，采用免疫组织化学检测其中KISS1与KAI1蛋白表达，分析结肠癌组织中KISS1和KAI1蛋白表达与患者临床参数的关系，及两者表达的相互关系。结果：KISS1与KAI1在结肠癌组织中表达较癌旁组织明显下降(P<0.05)；KISS1和KAI1表达与患者年龄、性别、肿瘤大小均无明显相关性(P>0.05)，KISS1和KAI1表达与患者肿瘤分化程度、淋巴转移及侵犯浆膜均有明显相关性；结肠癌组织中KISS1表达和KAI1表达呈正相关(P<0.05)；KISS1和KAI1阴性表达患者的 5年生存率均明显低于阳性表达患者(P<0.05)。结论：KISS1和KAI1在结肠癌中低表达，与结肠癌恶性生物学行为有关，对评价结肠癌患者预后具有一定的提示意义。
关键词：
结肠癌；转移；预后；KISS1；KAI1
Expression and clinical significance of KISS1 and KAI1 in colon cancer
CorrespondingAuthor: WANG Zheyan Email: 153874817@qq.com
DOI: 10.3978/j.issn.2095-6959.2019.03.008
Foundation: This work was supported by Health and Family Planning Commission of Hebei Province, China (20181235).
Abstract
Objective: To explore the expression and clinical significance of KISS1 and KAI1 in colon cancer tissues. Methods: The postoperative pathological specimens of 80 patients with colon cancer were collected, and all the specimens were detected for the expressions of KISS1 and KAI1 proteins by immunochemistry, and the relationship between the clinical parameters and the expressions of KISS1 and KAI1 proteins in colon cancer tissues was analyzed. Results: The expression of KISS1 and KAI1 in colon cancer tissues was significantly lower than that in adjacent tissues (P<0.05). The expression of KISS1 and KAI1 was significantly associated with tumor differentiation degree, lymphatic metastasis and invasion of serosa layer (P<0.05), while not significantly related with age, gender and tumor size (P>0.05). KISS1 expression was positively correlated with KAI1 expression in colon cancer tissues (P<0.05). The 5-year survival rate of patients with negative KISS1 and KAI1 expression was significantly lower than that of patients with positive expression (P<0.05). Conclusion: The low expression of KISS1 and KAI1 in colon cancer is related to the malignant biological behavior of colon cancer, which is of great significance to evaluate the prognosis of patients with colon cancer.
Keywords：
colon cancer; metastasis; prognosis; KISS1; KAI1