Objective: To investigate the application effect of home-based intermediate care network service platform in patients with acute myocardial infarction (AMI) after percutaneous coronary intervention (PCI). Methods: Ninety-four patients with AMI in cardiology department of a top three hospital in Beijing were selected by convenient sampling method, and these patients were randomly divided into an observation group and a control group. Patients in the observation group were intervened in home-based intermediate care based on internet service platform, and patients in the control group were followed up routinely. After 4 weeks, the control of cardiovascular risk factors, exercise tolerance, living quality, psychological status and self-care ability were compared between the two groups. Results: After intervention for 4 weeks, salt intake, smoking cases of patients in the observation group were significantly lower than the control group (P<0.05); the scores of exercise tolerance, self-care ability and living quality of patients in the observation group were significantly higher than those in the control group (P<0.05); the anxiety and depression scores in the observation group were significantly lower than those in the control group (P<0.05). Conclusion: Home-based intermediate care network service platform can effectively control postoperative AMI risk factors, improve their exercise tolerance, living quality and self-care ability, and reduce their anxiety and depression.