维生素D与慢性肾脏病的肾脏保护作用及相关机制
| 作者: |
1史千玉,
1杨莎莎,
1吴红赤
1 哈尔滨医科大学附属第一医院肾内科，哈尔滨 150001 |
| 通讯: |
吴红赤
Email: 2462684173@qq.com |
| DOI: | 10.3978/j.issn.2095-6959. 2018.12.027 |
| 基金: | 黑龙江省教育厅科学技术研究项目(12541264)。 |
摘要
维生素D是一种在人体组织器官中广泛表达的类固醇激素，与核激素受体维生素D受体(vitamin D receptor，VDR)结合发挥生物学效应。慢性肾脏病(chronic kidney disease，CKD)是肾结构和功能的不可逆性改变，CKD患者普遍缺乏维生素D。近年来研究发现缺乏维生素D不仅可以导致钙、磷、甲状旁腺激素代谢紊乱，也会加速CKD进展，增加CKD患者心血管疾病、感染、肾性贫血的发生率。
关键词：
维生素D；慢性肾脏病；肾脏保护
Renal protective effect and related mechanism of vitamin D and chronic kidney disease
CorrespondingAuthor: WU Hongchi Email: 2462684173@qq.com
DOI: 10.3978/j.issn.2095-6959. 2018.12.027
Foundation: This work was supported by the Heilongjiang Provincial Department of Education Science and Technology Research Project, China (12541264).
Abstract
Vitamin D is a steroid hormone widely expressed in human tissues and organs. It needs to bind to the nuclear hormone receptor vitamin D receptor (VDR) to exert biological effects. Chronic kidney disease (CKD) is an irreversible change in kidney structure and function, and vitamin D deficiency is common in CKD patients. In recent years, studies have found that vitamin D deficiency can not only lead to metabolic disorders of calcium, phosphorus and parathyroid hormone, but also accelerate the progression of CKD and increase the incidence of cardiovascular disease, infection, and renal anemia in patients with CKD.
Keywords：
vitamin D; chronic kidney disease; kidney protection