ANP32A表达与结直肠癌肝转移的相关性
| 作者: |
1杨光华,
2刘春玲,
3吕春秀,
1虞向阳,
1崔明新,
1张国志
1 华北理工大学附属医院普通外科，河北 唐山 063000 2 唐山人民医院病理科，河北 唐山 063000 3 华北理工大学附属医院血液内科，河北 唐山 063000 |
| 通讯: |
杨光华
Email: yangguanghua84@126.com |
| DOI: | 10.3978/j.issn.2095-6959. 2018.12.006 |
摘要
目的：研究酸性核酸蛋白32A(ac id ic leuc ine-r ich nuclear phosphoprotein，ANP32A)在结直肠癌肝转移中的临床意义。方法：应用免疫组织化学法检测156例结直肠癌组织(其中59例患者存在肝转移)中癌与癌旁组织的表达水平，并探讨其表达水平与结直肠癌肝转移的相关性。结果：ANP32A蛋白在结直肠癌组织中的阳性表达率为59.6%(93/156)，癌旁组织的阳性表达率为19.9%(31/156)，差异具有统计学意义( P<0.05)。ANP32A在肝转移患者中的阳性表达率79.7%(47/59)，明显高于无肝转移患者中的阳性表达率47.4%(46/97)，差异具有统计学意义(P<0.05)。单因素分析结果显示肿瘤的分化程度、淋巴结转移以及ANP32A的表达与肝转移相关(均P<0.05)。多因素logistic回归分析结果提示肿瘤分化程度及ANP32A蛋白阳性表达是结直肠癌肝转移的独立危险因素(均P<0.05)。结论：ANP32A在结直肠癌中的高表达与结直肠癌肝转移相关，可望成为结直肠癌肝转移治疗的潜在靶点。
关键词：
结直肠癌；肝转移；临床病理参数；酸性核酸蛋白32A
Correlation of expression of ANP32A with live metastasis in colorectal cancer
CorrespondingAuthor: YANG Guanghua Email: yangguanghua84@126.com
DOI: 10.3978/j.issn.2095-6959. 2018.12.006
Abstract
Objective: To investigate the expression of ANP32A in colorectal cancer with liver metastasis. Methods: Immunohistochemistry was used to analyze the expressions of ANP32A in 156 colorectal cancer specimens and matched paratumorous normal specimens (59 patients with liver metastasis). The correlation of ANP32A expression level with colorectal cancer liver metastasis was carried out. Results: The higher expression of ANP32A were found in colorectal specimens compared with matched paratumorous normal specimens (P<0.05), the positive rates were 59.6% and 19.9%, respectively. Expression of ANP32A in patients with liver metastasis was significantly higher than that in patients without liver metastasis (79.7% vs 47.4%). Single factor analysis showed that liver metastasis was associated with histological differentiation, lymph node metastasis, and the expression of ANP32A (all P<0.05). Multivariate logistic regression analysis further showed that histological differentiation and higher expression of ANP32A were independent risk factor in colorectal cancer with liver metastasis. Conclusion: The overexpression of ANP32A is associated with carcinogenesis and liver metastasis of CRC, which suggests that the positive expression of ANP32A may be the potential target in CRC with liver metastasis.
Keywords：
colorectal cancer; liver metastasis; clinicopathological features; acidic leucine-rich nuclear phosphoprotein