Objective: To investigate the clinical and laboratory characteristics of lupus nephritis with lupus serositis. Methods: A total of 113 patients of lupus nephritis who hospitalized in Department of Nephropathy of Second Hospital of Jilin University were divided into a serositis group (60 cases) and a non-serositis group (63 cases) according to whether complicated with lupus serositis. A comparative analysis of clinical and laboratory characteristics was performed between the two groups. Results: The prevalence of serositis in lupus nephritis was 53.10%. In the serositis group, the most common type of pathology was IV+V (41.67%), followed by type IV (33.33%), the most common clinical renal damage is nephrotic syndrome (41.67%). The hematological system damaged more common in the serositis group, among which anemia was most common (85%). There were differences between the two groups in Alb, anti-Sm, complement, Cys-C, Scr, urine protein, SLEDIA score. Conclusion: Lupus nephritis with lupus serositis suggests higher activity of the SLE. Early diagnosis and start treatment of systemic lupus erythematosus (SLE) have important clinical significance.