Objective: To investigate the clinical features and therapy of different Wagner classification diabetes foot patients. Methods: Sixty-two diabetic foot patients were classified into Wagner 2–4 grades according to the severity of diabetic foot ulcer. Biochemical test, medication and local treatment were taken. The features of ulcer and recovery and the factors influencing healing were assessed. Results: With the increase of Wagner’s grades, the peripheral artery disease was more serious, wound-healing times were longer, the levels of serum Cyst-C, homocysteine and serum uric acid were all increased significantly (P<0.05). The bacterial floras were transformed from gram-positive to gram-negative rods with rising Wagner’s grades. Conclusion: The levels of serum Cyst-C, homocysteine and uric acid regarded as indicators of the disease severity. Improving the blood supplying of the limbs is the basis of which cure diabetes foot. Proportion of gram-negative bacilli seems to increase in patients with severe diabetic foot ulcer and requiring appropriate application of antibiotics.