Objective: To analyze the quantitative parameters of dynamic contrast enhanced-magnetic resonance imaging (DCE-MRI) in patients with different molecular subtypes of breast cancer. Methods: A total of 140 patients with breast cancer who were admitted to the hospital during the period from June 2015 to June 2018 were enrolled. All patients underwent DCE-MRI scanning. The pathological and immunohistochemical examinations were performed on the resected lesions after surgery. The breast cancer was divided into four different molecular subtypes according to different molecular subtypes. Quantitative parameters of DCE-MRI [capacity transfer constant (Ktrans), rate constant (Kep), extravascular space to volume ratio (Ve)] and angiogenesis[vascular endothelial growth factors (VEGF), microvessel density (MVD)] were compared among different molecular subtypes and their correlations were analyzed. Results: The Ktrans and Kep of Luminal type A and Luminal type B were lower than those of triple negative type and HER-2 overexpression type. The Ve of the Luminal type A, Luminal type B and HER-2 overexpression type was higher than that of the three-negative type (all P<0.05). VEGF and MVD in patients with triple negative type were greater than those in patients with the other subtypes (P<0.05). Correlation analysis showed that VEGF and MVD were positively correlated with Ktrans and Kep, and negatively correlated with Ve in patients with triple negative breast cancer. MVD was positively correlated with Ktrans and negatively correlated with Ve in patients with Luminal A and Luminal B type breast cancer. MVD was positively correlated with Ktrans in patients with HER-2 overexpression type breast cancer (P<0.05). Conclusion: There are obvious differences in quantitative parameters of DCE-MRI between patients with different molecular subtypes of breast cancer, and they are closely related to angiogenesis in patients, especially in patients with triple negative breast cancer.